Project(s) for intake 2021:
The objective of the project is to investigate factors associated with the differences in susceptibility and progression of patients infected with SARS-CoV-2. COVID-19 is characterized by significant differences in host response, ranging from asymptomatic, mild, moderate, and extremely severe clinical manifestations. Increased severity in SARS-CoV-2 is associated with a number of factors including male sex, being elderly as well as with co-morbidities such as hypertension, type 2 diabetes, obesity, and cardiovascular disease. Many severe symptoms result from the impact of an inflammatory cytokine storm, thrombosis leading to ARDS and heart failure, and kidney injury. The diverse range of an individual’s response to SARS-COV-2 is likely due to individual host susceptibility including those genetic variations impacting immune response, thrombosis, cardiovascular and endothelial health. Severe disease may develop because of an impaired ability of the immune system to clear the virus and the development of a high viral load. This project aims to analyze host factors associated with differences in progression.